SEC61B

Across TCGA cell cohorts, SEC61B RNA expression is significantly associated with the go_rna of many other GO terms, with 2,863 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible SEC61B-associated GO terms across cancer lineages are Proteasome assembly, Immunoglobulin heavy chain V-D-J recombination, and DNA replication proofreading. Each is linked with SEC61B in more than 8 cancer types. Because this analysis shows association rather than direction, both SEC61B-to-partner and partner-to-SEC61B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Proteasome assembly grouped by SEC61B-low versus SEC61B-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SEC61B→partner) and Y-score (partner→SEC61B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Proteasome assembly →	+0.077	+0.545	<.001	.002	3	9
URINARY_TRACT	Immunoglobulin heavy chain V-D-J recombination →	+0.136	+0.559	.002	.002	3	9
SOFT_TISSUE	DNA replication proofreading →	-0.174	-0.595	<.001	.003	3	8
OESOPHAGUS	Dolichyl monophosphate biosynthetic process →	+0.106	+0.805	.003	.001	3	8
CNS	Base-excision repair, gap-filling →	-0.123	-0.604	<.001	<.001	3	8
BONE	Response to platinum ion →	+0.139	+0.561	<.001	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,863 associations by consensus.

Proteasome assembly by SEC61B expression — SKIN

Explore this box plot interactively →