SEC61A2

Across TCGA pan-cancer cohorts, SEC61A2 mass-spec protein differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of SEC61A2’s most consistent transcriptional readouts.

The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where SEC61A2 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types SEC61A2 is over-expressed in tumor, although a few such as OV show the opposite, repressed pattern.

OV are the cancer types where SEC61A2 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SEC61A2 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
OV	All	All	−0.960	.046	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 1 strongest of 1 lineages.

SEC61A2–OV

Open the OV breakdown →