SEC61A1

Across TCGA pan-cancer cohorts, SEC61A1 Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated SEC61A1 data layer compared with 22 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher SEC61A1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SEC61A1 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

BRCA, UCEC, and LGG are the cancer types where SEC61A1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	OS	Median	II,III,IV	0.514	0.958	<.001	28	view →
UCEC	OS	Median	All	1.000	0.649	.017	22	view →
LGG	OS	Median	All	0.163	0.889	<.001	10	view →
SKCM	DFS	Median	All	0.134	0.728	.004	9	view →
LUSC	OS	Median	All	0.005	0.819	<.001	6	view →
COAD	OS	Median	III,IV	0.157	0.791	.001	6	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

SEC61A1–BRCA (OS)

Open the BRCA breakdown →