SEC61A1

Across TCGA pan-cancer cohorts, SEC61A1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated SEC61A1 data layer compared with 22 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SEC61A1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SEC61A1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

HNSC, CCRCC, and PDAC are the cancer types where SEC61A1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	All	0.806	0.492	<.001	61	view →
CCRCC	OS	Quartile	All	0.404	1.000	.001	60	view →
PDAC	DFS	Tertile	All	0.559	0.881	.001	34	view →
GBM	DFS	Quartile	All	0.214	0.438	.002	15	view →
LUAD	DFS	Median	All	0.968	0.829	.006	6	view →
UCEC	DFS	Quartile	All	0.839	1.000	.031	4	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

SEC61A1–HNSC (DFS)

Open the HNSC breakdown →