SEC61A1

Across TCGA patient cohorts, SEC61A1 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. COAD shows the largest number of these associations.

The most reproducible SEC61A1-associated genes across cancer lineages are Di-Ras3, INPP4B, and Akt. Each is linked with SEC61A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SEC61A1-to-partner and partner-to-SEC61A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Di-Ras3 grouped by SEC61A1-low versus SEC61A1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEC61A1→partner) and Y-score (partner→SEC61A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Di-Ras3 →	-0.213	-2.991	.035	.036	3	2
UCEC	INPP4B →	-0.319	-1.794	.016	.027	3	2
UCEC	Akt →	-0.211	-2.311	.025	.034	3	2
UCEC	ATM →	-0.565	-2.459	.002	.019	3	2
UCEC	4E-BP1 →	+0.271	+2.351	.015	.018	3	2
COAD	Lck →	+0.831	+3.025	<.001	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

Di-Ras3 by SEC61A1 expression — COAD

Explore this box plot interactively →