SEC61A1

Across TCGA cell cohorts, SEC61A1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,181 significant associations in total. BONE shows the largest number of these associations.

The most reproducible SEC61A1-associated GO terms across cancer lineages are Golgi transport vesicle coating, COPI coating of Golgi vesicle, and SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition. Each is linked with SEC61A1 in more than 15 cancer types. Because this analysis shows association rather than direction, both SEC61A1-to-partner and partner-to-SEC61A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Golgi transport vesicle coating grouped by SEC61A1-low versus SEC61A1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SEC61A1→partner) and Y-score (partner→SEC61A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Golgi transport vesicle coating →	+0.140	+1.130	<.001	<.001	3	15
BONE	COPI coating of Golgi vesicle →	+0.140	+1.130	<.001	<.001	3	15
LIVER	SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition →	+0.147	+0.998	.001	<.001	2	16
BONE	Regulation of intracellular transport →	+0.078	+1.094	<.001	<.001	3	15
BONE	COPI-coated vesicle budding →	+0.140	+1.130	<.001	<.001	3	15
OESOPHAGUS	Endoplasmic reticulum to cytosol transport →	+0.206	+1.074	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,181 associations by consensus.

Golgi transport vesicle coating by SEC61A1 expression — BONE

Explore this box plot interactively →