SEC61A1

Across TCGA cell cohorts, SEC61A1 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. URINARY_TRACT shows the largest number of these associations.

The most reproducible SEC61A1-associated genes across cancer lineages are PTH, FAM163B, and OR4A47. Each is linked with SEC61A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SEC61A1-to-partner and partner-to-SEC61A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PTH grouped by SEC61A1-low versus SEC61A1-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEC61A1→partner) and Y-score (partner→SEC61A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	PTH →	+0.073	+5.087	<.001	.004	3	1
URINARY_TRACT	FAM163B →	+0.076	+5.087	<.001	.004	3	1
URINARY_TRACT	OR4A47 →	+0.026	+5.087	<.001	.004	3	1
URINARY_TRACT	PRSS58 →	+0.136	+5.087	<.001	.004	3	1
LARGE_INTESTINE	INSL5 →	+0.333	+3.655	<.001	.003	3	1
LARGE_INTESTINE	OR10W1 →	+0.014	+3.562	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

PTH by SEC61A1 expression — URINARY_TRACT

Explore this box plot interactively →