SEC24D

Across TCGA pan-cancer cohorts, SEC24D mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated SEC24D data layer compared with 25 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher SEC24D mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SEC24D expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

CCRCC, LSCC, and PDAC are the cancer types where SEC24D mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	All	0.461	0.973	<.001	63	view →
LSCC	DFS	Tertile	II,III,IV	0.639	0.968	<.001	27	view →
PDAC	DFS	Median	IV	0.214	0.785	.006	10	view →
LUAD	OS	Tertile	All	0.765	0.895	.021	9	view →
GBM	DFS	Tertile	All	0.261	0.502	.003	6	view →
UCEC	DFS	Tertile	All	0.956	0.797	.031	4	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

SEC24D–CCRCC (DFS)

Open the CCRCC breakdown →