SEC24D

Across TCGA patient cohorts, SEC24D mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SEC24D-associated genes across cancer lineages are PDCD4, E-Cadherin, and MEK1. Each is linked with SEC24D in more than 1 cancer types. Because this analysis shows association rather than direction, both SEC24D-to-partner and partner-to-SEC24D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by SEC24D-low versus SEC24D-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEC24D→partner) and Y-score (partner→SEC24D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	PDCD4 →	-0.523	-3.321	.012	.010	3	2
SKCM	E-Cadherin →	-1.149	-3.000	.011	.035	3	2
UCEC	MEK1 →	+0.348	+2.321	.001	<.001	3	2
UCEC	Notch1 →	+0.127	+1.064	.003	.048	3	2
UCEC	Annexin-1 →	+0.679	+2.321	<.001	<.001	3	2
UCEC	TFRC →	+0.431	+1.473	.008	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

PDCD4 by SEC24D expression — SKCM

Explore this box plot interactively →