SEC24D

Across TCGA cell cohorts, SEC24D mutation is significantly associated with the RNA expression of many other genes, with 349 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SEC24D-associated genes across cancer lineages are MSH4, GCAT, and CBY1. Each is linked with SEC24D in more than 1 cancer types. Because this analysis shows association rather than direction, both SEC24D-to-partner and partner-to-SEC24D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH4 grouped by SEC24D-low versus SEC24D-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEC24D→partner) and Y-score (partner→SEC24D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MSH4 →	+0.335	+2.827	<.001	.002	3	2
LARGE_INTESTINE	GCAT →	+1.175	+3.364	.003	.002	3	1
LARGE_INTESTINE	CBY1 →	+0.786	+3.459	<.001	.001	3	1
LARGE_INTESTINE	RPL3 →	+0.525	+3.237	.002	.003	3	1
LARGE_INTESTINE	PARD6A →	+0.915	+3.451	<.001	.002	3	1
LARGE_INTESTINE	NISCH →	+0.684	+3.067	.005	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 349 associations by consensus.

MSH4 by SEC24D expression — LARGE_INTESTINE

Explore this box plot interactively →