SEC24C

Across TCGA pan-cancer cohorts, SEC24C mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated SEC24C data layer compared with 25 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher SEC24C mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated SEC24C expression acts as an unfavorable survival marker, although some lineages such as UCEC and LSCC show a favorable association.

CCRCC, COAD, and UCEC are the cancer types where SEC24C mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	All	0.903	1.000	.013	14	view →
COAD	DFS	Median	IV	0.565	1.000	.028	6	view →
UCEC	DFS	Quartile	All	0.933	0.789	.044	6	view →
LSCC	DFS	Tertile	All	1.000	0.432	.013	6	view →
PDAC	DFS	Tertile	II,III,IV	0.473	0.277	.021	5	view →
OV	DFS	Median	All	1.000	0.863	.038	4	view →
LUAD	DFS	Quartile	II,III,IV	0.389	0.836	.022	4	view →
GBM	DFS	Median	All	0.410	0.227	.048	2	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

SEC24C–CCRCC (OS)

Open the CCRCC breakdown →