SEC24C

Across TCGA cell cohorts, SEC24C mutation is significantly associated with the RNA expression of many other genes, with 191 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SEC24C-associated genes across cancer lineages are KRT6C, SPATS1, and CLRN2. Each is linked with SEC24C in more than 1 cancer types. Because this analysis shows association rather than direction, both SEC24C-to-partner and partner-to-SEC24C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRT6C grouped by SEC24C-low versus SEC24C-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEC24C→partner) and Y-score (partner→SEC24C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	KRT6C →	+0.026	+4.037	<.001	.004	3	2
SOFT_TISSUE	SPATS1 →	+0.595	+4.977	<.001	.002	3	1
BREAST	CLRN2 →	+0.024	+4.196	<.001	.006	3	1
BREAST	PCDH11Y →	+0.035	+4.614	<.001	<.001	3	1
CNS	SLURP1 →	+0.338	+4.315	<.001	.006	3	1
CNS	SPRR2G →	+0.103	+5.285	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 191 associations by consensus.

KRT6C by SEC24C expression — BLOOD_Leukemia

Explore this box plot interactively →