SEC24B

Across TCGA patient cohorts, SEC24B mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SEC24B-associated genes across cancer lineages are ATM, 4E-BP1, and Rictor_pT1135. Each is linked with SEC24B in more than 2 cancer types. Because this analysis shows association rather than direction, both SEC24B-to-partner and partner-to-SEC24B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by SEC24B-low versus SEC24B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEC24B→partner) and Y-score (partner→SEC24B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.540	-3.794	<.001	<.001	3	3
UCEC	4E-BP1 →	+0.270	+3.807	.002	<.001	3	3
LUSC	Rictor_pT1135 →	-0.158	-3.160	.009	.019	3	2
UCEC	JNK2 →	+0.201	+1.727	.001	.023	3	2
UCEC	p62 Lck ligand →	+0.250	+1.817	.018	.015	3	2
UCEC	PRAS40_pT246 →	+0.134	+1.235	.016	.023	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

ATM by SEC24B expression — UCEC

Explore this box plot interactively →