SEC24B

Across TCGA cell cohorts, SEC24B mutation is significantly associated with the RNA expression of many other genes, with 247 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SEC24B-associated genes across cancer lineages are UCP1, OR13C5, and NPVF. Each is linked with SEC24B in more than 1 cancer types. Because this analysis shows association rather than direction, both SEC24B-to-partner and partner-to-SEC24B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UCP1 grouped by SEC24B-low versus SEC24B-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEC24B→partner) and Y-score (partner→SEC24B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	UCP1 →	+0.174	+3.999	.005	.005	3	2
CNS	OR13C5 →	+0.098	+4.772	<.001	.002	3	2
SOFT_TISSUE	NPVF →	+0.015	+4.930	<.001	.008	3	1
SOFT_TISSUE	LYPD2 →	+0.098	+5.369	<.001	.004	3	1
SOFT_TISSUE	GALP →	+0.030	+4.930	.008	.008	3	1
UPPER_AERODIGESTIVE_TRACT	MTRNR2L6 →	+0.173	+5.357	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 247 associations by consensus.

UCP1 by SEC24B expression — BLOOD_Leukemia

Explore this box plot interactively →