SEC23IP

Across TCGA pan-cancer cohorts, SEC23IP mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated SEC23IP data layer compared with 22 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher SEC23IP mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated SEC23IP expression acts as an unfavorable survival marker, although some lineages such as PDAC and GBM show a favorable association.

PDAC, GBM, and HNSC are the cancer types where SEC23IP mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Median	II,III,IV	0.905	0.777	.003	41	view →
GBM	DFS	Quartile	All	0.582	0.216	.004	11	view →
HNSC	OS	Median	All	1.000	0.449	.023	7	view →
LUAD	OS	Tertile	III,IV	0.784	0.490	.019	7	view →
CCRCC	OS	Quartile	All	0.690	1.000	.026	2	view →
LSCC	OS	Quartile	All	0.758	0.924	.034	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

SEC23IP–PDAC (OS)

Open the PDAC breakdown →