SEC23IP

Across TCGA pan-cancer cohorts, SEC23IP mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of SEC23IP’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where SEC23IP mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types SEC23IP is over-expressed in tumor, although a few such as PDAC show the opposite, repressed pattern.

LUAD, COAD, and PDAC are the cancer types where SEC23IP tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SEC23IP mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	All	+0.394	<.001	9	view →
COAD	Male	All	+0.109	<.001	8	view →
PDAC	Female	All	−0.238	<.001	5	view →
HNSC	Male	IV	+0.194	.002	5	view →
LSCC	Male	All	+0.144	<.001	4	view →
OV	All	All	+0.231	.038	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

SEC23IP–LUAD

Open the LUAD breakdown →