SEC23IP

Across TCGA patient cohorts, SEC23IP mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SEC23IP-associated genes across cancer lineages are ATM, A-Raf_pS299, and XBP1. Each is linked with SEC23IP in more than 2 cancer types. Because this analysis shows association rather than direction, both SEC23IP-to-partner and partner-to-SEC23IP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by SEC23IP-low versus SEC23IP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEC23IP→partner) and Y-score (partner→SEC23IP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.394	-2.687	.007	.005	3	3
UCEC	A-Raf_pS299 →	-0.120	-1.222	.001	.035	3	2
UCEC	XBP1 →	-0.149	-1.584	.001	.017	3	2
UCEC	ASNS →	+0.367	+1.502	.001	.027	3	2
UCEC	Cyclin-B1 →	+0.635	+2.906	<.001	.001	3	2
UCEC	14-3-3_beta →	-0.096	-1.973	.003	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

ATM by SEC23IP expression — UCEC

Explore this box plot interactively →