SEC23IP

Across TCGA cell cohorts, SEC23IP mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible SEC23IP-associated genes across cancer lineages are NXF5, IL20, and FAM205A. Each is linked with SEC23IP in more than 1 cancer types. Because this analysis shows association rather than direction, both SEC23IP-to-partner and partner-to-SEC23IP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NXF5 grouped by SEC23IP-low versus SEC23IP-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEC23IP→partner) and Y-score (partner→SEC23IP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	NXF5 →	+0.023	+2.882	<.001	.005	3	1
LARGE_INTESTINE	IL20 →	+0.170	+3.662	.001	.009	3	1
LARGE_INTESTINE	FAM205A →	+0.020	+3.444	<.001	.001	3	1
LUNG_NSCLC_LUAD	OR52N1 →	+0.040	+4.544	.008	.003	3	1
LUNG_NSCLC_LUAD	MRGPRG →	+0.026	+4.544	<.001	.003	3	1
LUNG_NSCLC_LUAD	OR4C12 →	+0.017	+4.662	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

NXF5 by SEC23IP expression — LARGE_INTESTINE

Explore this box plot interactively →