SEC23A

Across TCGA pan-cancer cohorts, SEC23A mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SEC23A data layer compared with 26 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher SEC23A mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SEC23A expression acts as an unfavorable survival marker, although some lineages such as LUAD and GBM show a favorable association.

PDAC, LUAD, and LSCC are the cancer types where SEC23A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Quartile	III,IV	0.212	0.884	.006	19	view →
LUAD	DFS	Quartile	III,IV	0.996	0.590	.008	9	view →
LSCC	OS	Tertile	All	0.669	1.000	.008	6	view →
CCRCC	DFS	Median	All	0.718	0.880	.027	5	view →
GBM	DFS	Median	All	0.403	0.241	.049	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SEC23A–PDAC (DFS)

Open the PDAC breakdown →