SEC23A

Across TCGA patient cohorts, SEC23A mutation is significantly associated with the RNA expression of many other genes, with 3,317 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SEC23A-associated genes across cancer lineages are RNA5SP421, ATP5F1A, and SAR1B. Each is linked with SEC23A in more than 2 cancer types. Because this analysis shows association rather than direction, both SEC23A-to-partner and partner-to-SEC23A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP421 grouped by SEC23A-low versus SEC23A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEC23A→partner) and Y-score (partner→SEC23A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP421 →	+0.538	+1.866	<.001	<.001	3	3
UCEC	ATP5F1A →	+0.401	+1.847	.002	<.001	3	2
UCEC	SAR1B →	+0.459	+2.416	<.001	<.001	3	2
UCEC	CENPH →	+0.699	+2.126	<.001	<.001	3	2
UCEC	SKA1 →	+0.759	+2.443	<.001	<.001	3	2
UCEC	CXCL13 →	+2.220	+3.906	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,317 associations by consensus.

RNA5SP421 by SEC23A expression — UCEC

Explore this box plot interactively →