SEC23A

Across TCGA patient cohorts, SEC23A mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SEC23A-associated genes across cancer lineages are ERK2, p21, and Shc_pY317. Each is linked with SEC23A in more than 1 cancer types. Because this analysis shows association rather than direction, both SEC23A-to-partner and partner-to-SEC23A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by SEC23A-low versus SEC23A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEC23A→partner) and Y-score (partner→SEC23A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.226	+2.321	<.001	.005	3	2
UCEC	p21 →	+0.164	+1.874	.010	.002	3	2
UCEC	Shc_pY317 →	-0.206	-2.201	<.001	<.001	3	2
UCEC	VHL →	-0.899	-2.070	<.001	.001	3	2
UCEC	ATM →	-0.550	-1.874	<.001	.002	3	2
UCEC	Caspase-7-cleavedD198 →	+0.730	+1.785	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

ERK2 by SEC23A expression — UCEC

Explore this box plot interactively →