SEC23A

Across TCGA cell cohorts, SEC23A mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SEC23A-associated genes across cancer lineages are MTRNR2L6, EPPIN, and NKX2-6. Each is linked with SEC23A in more than 1 cancer types. Because this analysis shows association rather than direction, both SEC23A-to-partner and partner-to-SEC23A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTRNR2L6 grouped by SEC23A-low versus SEC23A-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEC23A→partner) and Y-score (partner→SEC23A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	MTRNR2L6 →	+0.130	+4.357	<.001	.006	3	1
BLOOD_Leukemia	EPPIN →	+0.006	+4.922	.005	.009	3	1
BLOOD_Leukemia	NKX2-6 →	+0.639	+5.201	<.001	.006	3	1
BLOOD_Leukemia	OR52E4 →	+0.012	+5.201	.008	.006	3	1
BLOOD_Leukemia	TEX43 →	+0.141	+5.969	<.001	.001	3	1
BLOOD_Leukemia	OC90 →	+0.013	+5.201	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

MTRNR2L6 by SEC23A expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →