SEC22A

Across TCGA patient cohorts, SEC22A protein abundance is significantly associated with the RNA expression of many other genes, with 11,167 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible SEC22A-associated genes across cancer lineages are RPN1, COPG1, and SEC61A1. Each is linked with SEC22A in more than 5 cancer types. Because this analysis shows association rather than direction, both SEC22A-to-partner and partner-to-SEC22A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SEC22A versus RPN1 in LSCC, with a Pearson correlation of 0.47.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEC22A→partner) and Y-score (partner→SEC22A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RPN1 →	+0.457	+0.328	<.001	<.001	3	6
CCRCC	COPG1 →	+0.519	+0.352	<.001	<.001	3	6
LSCC	SEC61A1 →	+0.393	+0.353	<.001	<.001	3	6
UCEC	ICAM2 →	-0.586	-0.429	.002	.003	3	4
LSCC	DTX3L →	+0.671	+0.286	<.001	.001	3	4
LSCC	HSD17B10 →	+0.302	+0.240	.006	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,167 associations by consensus.

SEC22A vs RPN1 — LSCC

Explore this scatter interactively →