SEC22A

Across TCGA patient cohorts, SEC22A protein abundance is significantly associated with the protein abundance of many other proteins, with 19,950 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible SEC22A-associated proteins across cancer lineages are GOLGB1, SEC61A1, and SEC62_T158. Each is linked with SEC22A in more than 8 cancer types. Because this analysis shows association rather than direction, both SEC22A-to-partner and partner-to-SEC22A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SEC22A versus GOLGB1 in BRCA, with a Pearson correlation of 0.58.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SEC22A→partner) and Y-score (partner→SEC22A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	GOLGB1 →	+0.320	+0.362	<.001	<.001	3	9
BRCA	SEC61A1 →	+0.707	+0.472	<.001	<.001	3	8
BRCA	SEC62_T158 →	+1.176	+0.424	<.001	<.001	3	8
UCEC	SLC33A1 →	+0.787	+0.573	<.001	<.001	3	8
BRCA	TMTC3 →	+0.454	+0.385	<.001	<.001	3	8
BRCA	SEC62 →	+0.750	+0.439	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,950 associations by consensus.

SEC22A vs GOLGB1 — BRCA

Explore this scatter interactively →