SEC22A

Across TCGA patient cohorts, SEC22A mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SEC22A-associated genes across cancer lineages are TFRC, 14-3-3_beta, and FOXO3a_pS318_S321. Each is linked with SEC22A in more than 1 cancer types. Because this analysis shows association rather than direction, both SEC22A-to-partner and partner-to-SEC22A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFRC grouped by SEC22A-low versus SEC22A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEC22A→partner) and Y-score (partner→SEC22A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TFRC →	+0.552	+3.700	.025	.001	3	2
UCEC	14-3-3_beta →	-0.126	-2.973	.007	.035	3	1
UCEC	FOXO3a_pS318_S321 →	-0.139	-3.169	.016	.018	3	1
UCEC	GAPDH →	+0.501	+3.169	.045	.019	3	1
UCEC	Heregulin →	-0.140	-2.584	.015	.011	3	1
UCEC	JNK2 →	+0.329	+2.817	<.001	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

TFRC by SEC22A expression — UCEC

Explore this box plot interactively →