SEC1P

Across TCGA patient cohorts, SEC1P mutation is significantly associated with the RNA expression of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SEC1P-associated genes across cancer lineages are XKRY2, RNA5SP533, and ZBTB8OSP1. Each is linked with SEC1P in more than 1 cancer types. Because this analysis shows association rather than direction, both SEC1P-to-partner and partner-to-SEC1P results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, XKRY2 grouped by SEC1P-low versus SEC1P-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEC1P→partner) and Y-score (partner→SEC1P) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	XKRY2 →	+0.024	+4.184	.002	.009	3	1
STAD	RNA5SP533 →	+0.294	+5.206	<.001	.001	3	1
UCEC	ZBTB8OSP1 →	+0.383	+3.435	.002	.003	3	1
UCEC	RNU6-206P →	+0.317	+4.923	<.001	.002	3	1
UCEC	RNU6-767P →	+0.590	+3.701	<.001	.001	3	1
UCEC	RPL23AP4 →	+0.194	+3.302	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

XKRY2 by SEC1P expression — STAD

Explore this box plot interactively →