SEC16A

Across TCGA patient cohorts, SEC16A mutation is significantly associated with the total protein of many other genes, with 59 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SEC16A-associated genes across cancer lineages are ATM, INPP4B, and S6_pS240_S244. Each is linked with SEC16A in more than 4 cancer types. Because this analysis shows association rather than direction, both SEC16A-to-partner and partner-to-SEC16A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by SEC16A-low versus SEC16A-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEC16A→partner) and Y-score (partner→SEC16A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ATM →	-0.533	-2.406	<.001	.003	3	5
COAD	INPP4B →	-0.388	-2.406	.004	.003	3	4
UCEC	S6_pS240_S244 →	+0.253	+1.087	.015	.010	3	3
COAD	Caspase-7-cleavedD198 →	+0.832	+1.493	.003	.035	3	3
COAD	AMPK_pT172 →	-0.395	-1.898	.001	.016	3	3
LUSC	PKC-a →	+0.259	+3.027	.017	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 59 associations by consensus.

ATM by SEC16A expression — COAD

Explore this box plot interactively →