SEC16A

Across TCGA cell cohorts, SEC16A RNA expression is significantly associated with the go_rna of many other GO terms, with 4,068 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible SEC16A-associated GO terms across cancer lineages are Termination of RNA polymerase II transcription, RNA export from nucleus, and Regulation of chromatin organization. Each is linked with SEC16A in more than 14 cancer types. Because this analysis shows association rather than direction, both SEC16A-to-partner and partner-to-SEC16A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Termination of RNA polymerase II transcription grouped by SEC16A-low versus SEC16A-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SEC16A→partner) and Y-score (partner→SEC16A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Termination of RNA polymerase II transcription →	+0.103	+0.584	<.001	<.001	3	15
BONE	RNA export from nucleus →	+0.110	+0.570	<.001	<.001	3	13
KIDNEY	Regulation of chromatin organization →	+0.084	+0.753	.003	.006	3	12
BONE	Nucleic acid transport →	+0.102	+0.493	<.001	<.001	3	12
BONE	RNA transport →	+0.102	+0.493	<.001	<.001	3	12
BONE	Establishment of RNA localization →	+0.103	+0.610	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,068 associations by consensus.

Termination of RNA polymerase II transcription by SEC16A expression — SOFT_TISSUE

Explore this box plot interactively →