SEC16A

Across TCGA cell cohorts, SEC16A mutation is significantly associated with the RNA expression of many other genes, with 1,029 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SEC16A-associated genes across cancer lineages are PRSS38, CCR8, and ZNF584. Each is linked with SEC16A in more than 2 cancer types. Because this analysis shows association rather than direction, both SEC16A-to-partner and partner-to-SEC16A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRSS38 grouped by SEC16A-low versus SEC16A-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEC16A→partner) and Y-score (partner→SEC16A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	PRSS38 →	+0.058	+4.392	<.001	.003	3	3
OVARY	CCR8 →	+0.118	+2.807	<.001	.004	3	3
LARGE_INTESTINE	ZNF584 →	+0.594	+2.129	.002	.001	3	3
LARGE_INTESTINE	E2F2 →	+0.680	+3.169	.006	.006	3	3
LUNG_NSCLC_LUAD	OR4F5 →	+0.006	+3.472	<.001	.004	3	2
BLOOD_Leukemia	CSF2RB →	-2.184	-2.700	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,029 associations by consensus.

PRSS38 by SEC16A expression — OESOPHAGUS

Explore this box plot interactively →