Across TCGA pan-cancer cohorts, SEC14L6 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated SEC14L6 data layer compared with 1 for mutation status.
The strongest signal is observed in brain lower grade glioma (LGG), where higher SEC14L6 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SEC14L6 expression acts as an unfavorable survival marker, although some lineages such as KIRC and CESC show a favorable association.
LGG, UVM, and KIRC are the cancer types where SEC14L6 RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.