SEC14L5

Across TCGA pan-cancer cohorts, SEC14L5 Mutation is linked to patient survival in 11 of 34 cancer types, making it a survival-associated SEC14L5 data layer compared with 23 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher SEC14L5 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SEC14L5 expression acts as an unfavorable survival marker.

THYM, SCLC, and READ are the cancer types where SEC14L5 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Median	All	0.186	0.931	<.001	15	view →
SCLC	DFS	Median	II,III,IV	0.137	0.602	.008	12	view →
READ	OS	Median	II,III,IV	0.219	0.679	.006	12	view →
COAD	OS	Median	IV	0.082	0.659	<.001	12	view →
GBM	OS	Median	All	0.062	0.416	.001	9	view →
BLCA	DFS	Median	III,IV	0.132	0.572	.015	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
LUAD	OS	Median	All	0.209	0.672	.007	6	view →
LGG	DFS	Median	All	0.192	0.728	.007	3	view →
LIHC	OS	Median	II,III,IV	0.239	0.715	.035	3	view →
SKCM	OS	Median	All	0.102	0.395	.030	1	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

SEC14L5–THYM (OS)

Open the THYM breakdown →