SEC14L5

Across TCGA patient cohorts, SEC14L5 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SEC14L5-associated genes across cancer lineages are INPP4B, Annexin-1, and Caspase-7-cleavedD198. Each is linked with SEC14L5 in more than 2 cancer types. Because this analysis shows association rather than direction, both SEC14L5-to-partner and partner-to-SEC14L5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by SEC14L5-low versus SEC14L5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEC14L5→partner) and Y-score (partner→SEC14L5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	INPP4B →	-0.247	-2.584	.042	.010	3	3
UCEC	Annexin-1 →	+0.562	+2.019	.004	.017	3	3
COAD	Caspase-7-cleavedD198 →	+1.309	+2.824	<.001	.034	3	3
UCEC	PCNA →	+0.243	+3.321	.002	.009	3	2
UCEC	ATM →	-0.564	-2.687	<.001	.005	3	2
UCEC	Caspase-8 →	-0.269	-2.476	.004	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

INPP4B by SEC14L5 expression — UCEC

Explore this box plot interactively →