SEC14L5

Across TCGA cell cohorts, SEC14L5 mutation is significantly associated with the RNA expression of many other genes, with 25 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible SEC14L5-associated genes across cancer lineages are H1-8, TEX50, and FAM187B. Each is linked with SEC14L5 in more than 1 cancer types. Because this analysis shows association rather than direction, both SEC14L5-to-partner and partner-to-SEC14L5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, H1-8 grouped by SEC14L5-low versus SEC14L5-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEC14L5→partner) and Y-score (partner→SEC14L5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	H1-8 →	+0.059	+5.196	<.001	.005	3	2
LUNG_SCLC	TEX50 →	+0.030	+4.643	<.001	.004	3	2
BLOOD_Lymphoma	FAM187B →	+0.035	+4.058	<.001	.009	3	1
BLOOD_Lymphoma	ARHGEF15 →	+0.041	+3.843	.001	.007	3	1
BLOOD_Lymphoma	METTL11B →	+0.078	+4.606	.005	.001	3	1
BLOOD_Lymphoma	IGSF23 →	+0.259	+4.321	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

H1-8 by SEC14L5 expression — OVARY

Explore this box plot interactively →