SEC14L4

Across TCGA patient cohorts, SEC14L4 mutation is significantly associated with the RNA expression of many other genes, with 1,816 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SEC14L4-associated genes across cancer lineages are RNA5SP417, RNU6-1305P, and GOT1. Each is linked with SEC14L4 in more than 2 cancer types. Because this analysis shows association rather than direction, both SEC14L4-to-partner and partner-to-SEC14L4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP417 grouped by SEC14L4-low versus SEC14L4-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEC14L4→partner) and Y-score (partner→SEC14L4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RNA5SP417 →	+0.970	+4.882	<.001	.005	3	3
STAD	RNU6-1305P →	+0.593	+4.007	<.001	.001	3	3
SKCM	GOT1 →	+0.427	+3.623	.001	.001	3	3
SKCM	ECHS1 →	+0.291	+2.636	.005	.005	3	3
UCEC	TUBGCP5 →	+0.350	+2.550	.006	<.001	3	2
UCEC	TRAJ36 →	+0.481	+1.851	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,816 associations by consensus.

RNA5SP417 by SEC14L4 expression — LUSC

Explore this box plot interactively →