SEC14L4

Across TCGA patient cohorts, SEC14L4 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SEC14L4-associated genes across cancer lineages are JNK2, Notch1, and PCNA. Each is linked with SEC14L4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SEC14L4-to-partner and partner-to-SEC14L4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by SEC14L4-low versus SEC14L4-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEC14L4→partner) and Y-score (partner→SEC14L4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	JNK2 →	+0.239	+2.717	.008	.003	3	2
UCEC	Notch1 →	+0.113	+1.584	.026	.019	3	2
UCEC	PCNA →	+0.184	+2.321	.018	.001	3	2
UCEC	ATM →	-0.576	-3.687	<.001	.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.542	+2.019	.011	.017	3	2
UCEC	4E-BP1 →	+0.230	+2.029	.018	.017	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

JNK2 by SEC14L4 expression — SKCM

Explore this box plot interactively →