SEC14L4

Across TCGA cell cohorts, SEC14L4 RNA expression is significantly associated with the go_rna of many other GO terms, with 847 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible SEC14L4-associated GO terms across cancer lineages are Anaphase-promoting complex-dependent catabolic process, Protein localization to nucleus, and Response to ionizing radiation. Each is linked with SEC14L4 in more than 5 cancer types. Because this analysis shows association rather than direction, both SEC14L4-to-partner and partner-to-SEC14L4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Anaphase-promoting complex-dependent catabolic process grouped by SEC14L4-low versus SEC14L4-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SEC14L4→partner) and Y-score (partner→SEC14L4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Anaphase-promoting complex-dependent catabolic process →	+0.084	+1.374	.005	.008	3	5
BREAST	Protein localization to nucleus →	+0.044	+0.510	<.001	.006	2	6
PANCREAS	Response to ionizing radiation →	+0.045	+0.537	.002	.003	3	5
PANCREAS	Ribose phosphate biosynthetic process →	+0.049	+0.720	.009	.003	3	5
PANCREAS	Transcription initiation at RNA polymerase II promoter →	+0.031	+0.552	.009	.006	2	6
PANCREAS	Ribonucleotide biosynthetic process →	+0.045	+0.506	.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 847 associations by consensus.

Anaphase-promoting complex-dependent catabolic process by SEC14L4 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →