SEC14L4

Across TCGA cell cohorts, SEC14L4 mutation is significantly associated with the drug of many other genes, with 30 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SEC14L4-associated genes across cancer lineages are Mirin, Niraparib, and Dinaciclib. Each is linked with SEC14L4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SEC14L4-to-partner and partner-to-SEC14L4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mirin grouped by SEC14L4-low versus SEC14L4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEC14L4→partner) and Y-score (partner→SEC14L4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Mirin →	+0.401	+3.061	.018	.010	3	1
LARGE_INTESTINE	Niraparib →	+0.406	+3.061	.010	.010	3	1
LARGE_INTESTINE	Dinaciclib →	+0.506	+2.672	.029	.039	3	1
LARGE_INTESTINE	UNC0642 →	+0.225	+2.881	.010	.019	3	1
LARGE_INTESTINE	CP466722 →	+0.360	+3.067	.046	.009	3	1
LARGE_INTESTINE	Luminespib →	+0.648	+3.061	.018	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

Mirin by SEC14L4 expression — LARGE_INTESTINE

Explore this box plot interactively →