SEC14L3

Across TCGA patient cohorts, SEC14L3 mutation is significantly associated with the immune_cell of many other genes, with 8 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible SEC14L3-associated genes across cancer lineages are CLP, Eosinophils, and GMP. Each is linked with SEC14L3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SEC14L3-to-partner and partner-to-SEC14L3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CLP grouped by SEC14L3-low versus SEC14L3-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEC14L3→partner) and Y-score (partner→SEC14L3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	CLP →	+0.067	+2.478	.024	.010	3	2
SKCM	Eosinophils →	+0.057	+2.608	<.001	<.001	3	1
SKCM	GMP →	+0.023	+2.083	.010	.001	3	1
SKCM	Hepatocytes →	+0.012	+1.643	.024	.039	3	1
SKCM	Myocytes →	+0.035	+2.234	.012	.030	3	1
SKCM	Skeletal muscle →	+0.029	+1.684	.039	.014	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

CLP by SEC14L3 expression — SKCM

Explore this box plot interactively →