SEC14L3

Across TCGA cell cohorts, SEC14L3 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SEC14L3-associated genes across cancer lineages are MAGEB5, VSIG4, and RGS7. Each is linked with SEC14L3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SEC14L3-to-partner and partner-to-SEC14L3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEB5 grouped by SEC14L3-low versus SEC14L3-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEC14L3→partner) and Y-score (partner→SEC14L3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	MAGEB5 →	+0.033	+4.643	<.001	.008	3	1
LARGE_INTESTINE	VSIG4 →	+0.021	+2.791	.001	.005	3	1
BLOOD_Leukemia	RGS7 →	+0.336	+3.769	<.001	.008	3	1
BLOOD_Leukemia	OR10R2 →	+1.568	+3.551	<.001	.009	3	1
BLOOD_Leukemia	GSG1L2 →	+0.034	+4.384	<.001	.006	3	1
BLOOD_Leukemia	ACP7 →	+0.038	+4.230	<.001	.002	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

MAGEB5 by SEC14L3 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →