SEC14L2

Across TCGA pan-cancer cohorts, SEC14L2 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated SEC14L2 data layer compared with 26 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher SEC14L2 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated SEC14L2 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

LUAD, CCRCC, and LSCC are the cancer types where SEC14L2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	II,III,IV	0.380	0.856	.001	18	view →
CCRCC	DFS	Quartile	II,III,IV	0.290	0.746	.006	17	view →
LSCC	DFS	Tertile	All	0.622	0.866	.010	16	view →
UCEC	DFS	Tertile	All	0.945	0.808	.023	4	view →
GBM	DFS	Quartile	All	0.173	0.492	.025	4	view →
PDAC	OS	Median	IV	0.491	0.836	.024	3	view →
HNSC	OS	Median	IV	0.615	0.829	.037	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

SEC14L2–LUAD (OS)

Open the LUAD breakdown →