SEC14L1

Across TCGA pan-cancer cohorts, SEC14L1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SEC14L1 data layer compared with 23 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher SEC14L1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SEC14L1 expression acts as an unfavorable survival marker, although some lineages such as PDAC and CCRCC show a favorable association.

PDAC, LSCC, and LUAD are the cancer types where SEC14L1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Tertile	IV	0.752	0.205	.024	7	view →
LSCC	DFS	Median	All	0.909	0.964	.012	7	view →
LUAD	OS	Tertile	III,IV	0.329	0.904	.015	4	view →
CCRCC	OS	Tertile	III,IV	0.978	0.223	.036	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

SEC14L1–PDAC (DFS)

Open the PDAC breakdown →