SEC14L1

Across TCGA patient cohorts, SEC14L1 mutation is significantly associated with the RNA expression of many other genes, with 3,318 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SEC14L1-associated genes across cancer lineages are RITA1, KMT5A, and CDCA2. Each is linked with SEC14L1 in more than 3 cancer types. Because this analysis shows association rather than direction, both SEC14L1-to-partner and partner-to-SEC14L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RITA1 grouped by SEC14L1-low versus SEC14L1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEC14L1→partner) and Y-score (partner→SEC14L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RITA1 →	+0.395	+3.032	<.001	<.001	3	4
UCEC	KMT5A →	+0.422	+2.765	<.001	<.001	3	3
UCEC	CDCA2 →	+0.703	+3.606	<.001	.001	3	3
UCEC	UBE2G2 →	+0.291	+2.080	.005	<.001	3	3
UCEC	HEXIM1 →	+0.598	+3.928	<.001	<.001	3	3
UCEC	GPATCH3 →	+0.343	+2.112	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,318 associations by consensus.

RITA1 by SEC14L1 expression — UCEC

Explore this box plot interactively →