SEC14L1

Across TCGA patient cohorts, SEC14L1 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SEC14L1-associated genes across cancer lineages are ASNS, Di-Ras3, and Smad4. Each is linked with SEC14L1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SEC14L1-to-partner and partner-to-SEC14L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by SEC14L1-low versus SEC14L1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEC14L1→partner) and Y-score (partner→SEC14L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.380	+1.700	.004	.042	3	2
UCEC	Di-Ras3 →	-0.109	-1.861	.045	.049	3	2
SKCM	Smad4 →	+0.184	+3.321	.001	.010	2	3
UCEC	ERK2 →	+0.181	+3.459	.010	.005	3	1
UCEC	JNK2 →	+0.214	+1.502	.003	.030	3	1
UCEC	MEK1 →	+0.349	+1.847	.009	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

ASNS by SEC14L1 expression — UCEC

Explore this box plot interactively →