SEC14L1

Across TCGA cell cohorts, SEC14L1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,441 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SEC14L1-associated GO terms across cancer lineages are Negative regulation of RIG-I signaling pathway, Regulation of hippo signaling, and Protein depolymerization. Each is linked with SEC14L1 in more than 18 cancer types. Because this analysis shows association rather than direction, both SEC14L1-to-partner and partner-to-SEC14L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of RIG-I signaling pathway grouped by SEC14L1-low versus SEC14L1-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SEC14L1→partner) and Y-score (partner→SEC14L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Negative regulation of RIG-I signaling pathway →	+0.179	+1.703	<.001	<.001	3	19
STOMACH	Regulation of hippo signaling →	+0.101	+1.305	.001	<.001	3	13
LUNG_NSCLC_LUSC	Protein depolymerization →	+0.123	+1.358	<.001	.001	3	13
BONE	Actin filament depolymerization →	+0.165	+0.893	.001	.003	3	13
LUNG_NSCLC_LUSC	Positive regulation of supramolecular fiber organization →	+0.093	+1.346	.005	.002	3	12
LUNG_NSCLC_LUSC	Positive regulation of stress fiber assembly →	+0.104	+1.031	.002	.005	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,441 associations by consensus.

Negative regulation of RIG-I signaling pathway by SEC14L1 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →