SEC14L1

Across TCGA cell cohorts, SEC14L1 mutation is significantly associated with the RNA expression of many other genes, with 19 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SEC14L1-associated genes across cancer lineages are POTEB2, CFHR2, and MAGEB5. Each is linked with SEC14L1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SEC14L1-to-partner and partner-to-SEC14L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, POTEB2 grouped by SEC14L1-low versus SEC14L1-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEC14L1→partner) and Y-score (partner→SEC14L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	POTEB2 →	+0.012	+5.029	<.001	.006	3	2
LARGE_INTESTINE	CFHR2 →	+0.032	+3.700	<.001	.009	3	2
LUNG_NSCLC_LUSC	MAGEB5 →	+0.033	+4.643	<.001	.008	3	1
LARGE_INTESTINE	F13B →	+0.078	+3.772	<.001	.003	3	1
LARGE_INTESTINE	ITGAD →	+0.009	+2.925	.003	.007	3	1
LARGE_INTESTINE	ACSM6 →	+0.022	+3.584	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

POTEB2 by SEC14L1 expression — LUNG_SCLC

Explore this box plot interactively →