SEC11C

Across TCGA pan-cancer cohorts, SEC11C mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SEC11C data layer compared with 26 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher SEC11C mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SEC11C expression acts as an unfavorable survival marker, although some lineages such as LUAD and COAD show a favorable association.

LUAD, COAD, and HNSC are the cancer types where SEC11C mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Quartile	All	0.763	0.373	.002	19	view →
COAD	DFS	Median	IV	1.000	0.605	.043	6	view →
HNSC	DFS	Quartile	III,IV	0.783	0.554	.035	4	view →
CCRCC	OS	Median	II,III,IV	1.000	0.499	.025	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

SEC11C–LUAD (DFS)

Open the LUAD breakdown →