SEBOX

Across TCGA pan-cancer cohorts, SEBOX RNA is linked to patient survival in 15 of 34 cancer types, making it the most broadly survival-associated SEBOX data layer compared with 1 for mutation status.

The strongest signal is observed in small cell lung cancer (SCLC), where higher SEBOX RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated SEBOX expression acts as an unfavorable survival marker, although some lineages such as SCLC and PAAD show a favorable association.

SCLC, COAD, and LUSC are the cancer types where SEBOX RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SCLC	DFS	Quartile	All	0.786	0.481	.002	81	view →
COAD	DFS	Tertile	II,III,IV	0.496	0.763	.002	60	view →
LUSC	OS	Tertile	III,IV	0.249	0.702	<.001	54	view →
TGCT	DFS	Tertile	II,III,IV	0.629	1.000	.002	36	view →
UVM	OS	Tertile	III,IV	0.241	0.765	.002	33	view →
PRAD	DFS	Tertile	All	0.572	0.793	<.001	30	view →
SKCM	OS	Tertile	All	0.740	0.879	.001	24	view →
STAD	DFS	Quartile	All	0.544	0.692	.006	19	view →
PAAD	OS	Tertile	All	0.776	0.437	.020	18	view →
BLCA	OS	Tertile	III,IV	0.194	0.483	.016	18	view →
READ	DFS	Tertile	IV	0.027	0.636	<.001	18	view →
KIRP	OS	Tertile	II,III,IV	1.000	0.456	.041	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 15 lineages.

SEBOX–SCLC (DFS)

Open the SCLC breakdown →