SDSL

Across TCGA pan-cancer cohorts, SDSL mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SDSL data layer compared with 28 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher SDSL mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SDSL expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LUAD show a favorable association.

CCRCC, LUAD, and HNSC are the cancer types where SDSL mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	II,III,IV	0.814	0.481	.011	32	view →
LUAD	DFS	Median	II,III,IV	0.674	0.304	.007	21	view →
HNSC	DFS	Quartile	IV	0.906	0.607	.022	18	view →
LSCC	DFS	Tertile	II,III,IV	0.810	1.000	.025	5	view →
GBM	OS	Quartile	All	0.384	0.644	.021	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SDSL–CCRCC (DFS)

Open the CCRCC breakdown →