SDSL

Across TCGA patient cohorts, SDSL protein abundance is significantly associated with the RNA expression of many other genes, with 14,756 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SDSL-associated genes across cancer lineages are ATP8B4, SIGLEC8, and FGL2. Each is linked with SDSL in more than 5 cancer types. Because this analysis shows association rather than direction, both SDSL-to-partner and partner-to-SDSL results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SDSL versus ATP8B4 in GBM, with a Pearson correlation of 0.46.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SDSL→partner) and Y-score (partner→SDSL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ATP8B4 →	+0.630	+0.463	<.001	<.001	3	6
GBM	SIGLEC8 →	+1.086	+0.394	<.001	<.001	3	6
HNSC	FGL2 →	+0.723	+0.334	<.001	<.001	3	6
HNSC	ZMYND15 →	+0.576	+0.477	<.001	<.001	3	6
HNSC	FGD2 →	+0.825	+0.319	<.001	<.001	3	6
GBM	SCIMP →	+0.621	+0.548	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,756 associations by consensus.

SDSL vs ATP8B4 — GBM

Explore this scatter interactively →