SDSL

Across TCGA cell cohorts, SDSL RNA expression is significantly associated with the go_rna of many other GO terms, with 6,365 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SDSL-associated GO terms across cancer lineages are Protein targeting to vacuole involved in autophagy, L-threonine metabolic process, and L-threonine catabolic process. Each is linked with SDSL in more than 10 cancer types. Because this analysis shows association rather than direction, both SDSL-to-partner and partner-to-SDSL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein targeting to vacuole involved in autophagy grouped by SDSL-low versus SDSL-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SDSL→partner) and Y-score (partner→SDSL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Protein targeting to vacuole involved in autophagy →	+0.225	+2.441	<.001	<.001	3	11
CNS	L-threonine metabolic process →	+0.157	+0.975	<.001	<.001	3	11
CNS	L-threonine catabolic process →	+0.157	+0.975	<.001	<.001	3	11
BONE	Viral process →	+0.098	+2.827	<.001	<.001	3	10
LUNG_SCLC	Protein targeting to lysosome involved in chaperone-mediated autophagy →	+0.199	+2.190	<.001	<.001	3	10
BONE	Glycoprotein catabolic process →	+0.168	+2.147	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,365 associations by consensus.

Protein targeting to vacuole involved in autophagy by SDSL expression — BONE

Explore this box plot interactively →